Publication Lists

Professor Kimi Araki

Original articles

  1. Araki, K., Okada, Y., Araki, M. and Yamamura, K. Comparative analysis of right-element mutant lox sites on recombination efficiency in embryonic stem cells. BMC Biotechnol. 10: 29, 2010.
  2. Araki, K., Takeda, N., Yoshiki, A., Obata, Y., Nakagata, N., Shiroishi, T., Moriwaki, K. and Yamamura, K. Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain. Mamm Genome, 20(1): 14-20, 2009.
  3. Chen, H., Li, Z., Haruna, K., Li, Z., Li, Z., Semba, K., Araki, M., Yamamura, K. and Araki, K. Early pre-implantation lethality in mice carrying truncated mutation in the RNA polymerase 1-2 gene. Biochem. Biophys. Res. Commun. 365(4): 636-42, 2008.
  4. Yamamura, K. and Araki, K. Gene trap mutagenesis in mice: New perspectives and tools in cancer research. Cancer Sci. 99(1): 1-6, 2008.
  5. Hoshii, T., Takeo, T., Nakagata, N., Takeya, M., Araki, K. and Yamamura, K. LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice. Biol. Reprod.76(2): 303-13, 2007.
  6. Araki, K., Araki, M. and Yamamura, K. Negative selection with the Diphtheria toxin A fragment gene improves frequency of Cre-mediated cassette exchange in ES cells. J. Biochem. 140(6): 793-8, 2006.
  7. Miura, K., Yoshinobu, K., Imaizumi, T., Haruna, K., Miyamoto, Y., Yoneda, Y., Nakagata, N., Araki, M., Miyakawa, T., Yamamura, K. and Araki, K. Impaired expression of Importin/karyopherin β1 leads to post-implantation lethality. Biochem. Biophys. Res.Commun. 341(1): 132-8, 2006.
  8. Taniwaki, T., Haruna, K., Nakamura, H., Sekimoto, T., Oike, Y., Imaizumi, T., Saito, F., Muta, M., Soejima, Y., Utoh, A., Nakagata, N., Araki, M., Yamamura, K. and Araki, K. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-bgeo cassette. Dev. Growth Differ. 47(3):163-72, 2005.
  9. Miyata, K., Oike, Y., Hoshii, T., Maekawa, H., Ogawa, H., Suda, T., Araki, K. and Yamamura, K. Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the a/b hydrolase domain containing 2 gene. Biochem. Biophys. Res. Commun. 329(1): 296-304, 2005.
  10. Hino, H., Araki, K., Uyama, E., Takeya, M., Araki, M., Yoshinobu, K., Miike, K., Kawazoe, Y., Maeda, Y., Uchino, M. and Yamamura, K. Myopathy phenotype in transgenic mice expressing mutated PABPN1 as a model of oculopharyngeal muscular dystrophy. Hum. Mol. Genet. 13(2): 181-90, 2004.
  11. Araki, K., Araki, M. and Yamamura, K. Site-directed integration of the cre gene mediated by Cre recombinase using a combination of mutant lox sites. Nucleic Acids Res. 30(19): e103, 2002.
  12. Imaizumi, T., Araki, K., Miura, K., Araki, M., Suzuki, M., Terasaki, H. and Yamamura, K. Mutant mice lacking Crk-II caused by gene trap insertional mutagenesis: Crk-II is not essential for embryonic development. Biochem.Biophys. Res. Commun. 266(2): 569-74, 1999.
  13. Araki, K., Imaizumi, T., Sekimoto, T., Yoshinobu, K., Yoshimuta, J., Akizuki, M., Miura, K., Araki, M. and Yamamura, K. Exchangeable gene trap using the Cre/mutated lox system. Cell Mol. Biol. 45(5): 737-50, 1999.
  14. Oike, Y., Hata, A., Mamiya, T., Kaname, T., Noda, Y., Suzuki, M., Yasue, H., Nabeshima, T., Araki, K. and Yamamura, K. Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: Implication of a dominant negative mechanism. Human Mol. Genet. 8(3): 387-96, 1999.
  15. Araki, K., Imaizumi, T., Okuyama, K., Oike,Y. and Yamamura, K. Efficiency of recombination by Cre transient expression in embryonic stem cells: Comparison of various promoters. J. Biochem. 122(5): 977-82, 1997.
  16. Araki, K., Araki, M. and Yamamura,K. Targeted integration of DNA using mutant lox sites in embryonic stem cells. Nucleic Acids Res. 25(4): 868-72, 1997.
  17. Rodriguez, I., Araki, K., Karim, K., Martinou, J.-C. and Vassalli, P. Mouse vaginal opening is an apoptosis-dependent process which can be prevented by the overexpression of Bcl2. Dev. Biol. 184(1): 115-21, 1997.
  18. Biancone, L., Araki, M., Araki, K., Vassalli,P. and Stamenkovic, I. Reduction of tumor metastasis by expression of E-selectin in vivo. J. Exp. Med. 183(2): 581-7, 1996.
  19. Araki, K., Araki, M., Miyazaki, J. and Vassalli, P. Site specific recombination of transgene in fertilized eggs by transient expression of Cre recombinase. Proc. Natl. Acad. Sci., USA. 92(1): 160-4, 1995.
  20. Araki, K., Miyazaki, J., Hino, O., Tomita, N., Chisaka, O., Matsubara, K. and Yamamura, K. Expression and replication of hepatitis B virus genome in transgenic mice. Proc. Nathl. Acad. Sci. USA. 86(1): 207-11, 1989.


  1. Araki, M., Araki, K., Tsuruta, Y., Sakumura, Y., Muta, M., Keita, T., Koga, N., Egami, T., Kimachi, Y., Yoshinobu, K., Yamamura, K.: Database for the Exchangeable Gene Trap Clones (EGTC). The 4th Asian Mouse Mutagenesis and Resource Association. Dec. 17-18. 2009, Kumamoto (Japan)
  2. Araki, K., Takeda, N., Yoshiki, A., Yamada,G., Nakagata, N., Shiroishi, T,., Moriwaki, K. and Yamamura, K.: ESTABLISHMENT OF EMBRYONIC STEM CELL LINES DERIVED FROM MSM/MS STRAIN ORIGINATED FROM MUS MUSCULUS MOLOSSINUS., 21st International Mammalian Genome Conference IMGC2007, Oct.28-Nov.1. 2007, Kyoto(Japan)
  3. Araki, M., Araki, K., Yoshinobu, K., Haruna, K., Sakumura, Y. and Yamamura,K.: EGTC, DATABASE FOR THE EXCHANGEABLE GENE TRAP CLONES; RESOURCE OF MOUSE AND ES CELL LINES FOR THE FUNCTIONAL ABALYSIS OF THE MOUSE GENOME., 21st International Mammalian Genome Conference IMGC2007, Oct.28-Nov.1. 2007, Kyoto(Japan)
  4. Araki, K.: Alteration of a trap allele into four different alleles by using Cre/mutant lox system. 2004 International Gene Trap Workshop, 7.1-7.2. 2004, Cambridge(UK)
  5. Araki, K., Araki, M., Yamamura, K.: Efficient site cassette exchange using Cre/mutant-lox sysutem in ES cells, Frontiers in Genome Engineering Building a Better Mouse, 6.6-9. 2004, Nashville(U.S.A.)(Invited Talk)
  6. Araki, K.: Efficient gene replacement in exchangeable gene trap lines. 2nd International Gene Trap Workshop, 5.30-6.1. 2002, Frankfurt am Main(Germany)
  7. Araki, K., Araki, M., Imaizumi, T., Sekimoto, T., Yamamura, K.: Exchangeable gene trap using Cre/mutated lox system. Mouse Molecular Genetics Meeting, 9.1-5. 1999, Heidelberg(Germany)