研究業績

山村研一

原著論文

  1. Shen, J., Shi, D., Suzuki, T., Xia, Z., Zhang, H., Araki, K., Wakana, S., Takeda, N., Yamamura, K., Jin, S. and Li, Z. Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background. Lab. Invest. 96: 680-691, 2016.
  2. Takeda, N., Yoshinaga, K., Furushima, K., Takamune, K., Li, Z., Abe, S., Aizawa, S., Yamamura, K. Viable offspring obtained from Prm1-deficient sperm in mice. Sci Rep. 6: 27409, 2016.
  3. Mu, Y., Jin, S., Shen, J., Sugano, A., Takaoka, Y., Qiang, L., Imbimbo, B. P., Yamamura, K. and Li, Z. CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci. FEBS Lett. 589(7): 849-856, 2015.
  4. Semba, K., Araki, K., Matsumoto, K., Suda, H., Ando, T., Sei, A., Mizuta, H., Takagi, K., Nakahara, M., Muta, M., Yamada, G., Nakagata, N., Iida, A., Ikegawa, S., Nakamura, Y., Araki, M., Abe, K. and Yamamura, K. Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth’s short tail mice. PLoS Genet. 9(2): e1003204, 2013.
  5. Ando, T., Semba, K., Suda, H., Sei, A., Mizuta, H., Araki, M., Abe, K., Imai, K., Nakagata, N., Araki, K. and Yamamura, K. The floor plate is sufficient for development of the sclerotome and spine without the notochord. Mechanism Dev. 128(1-2): 129-40, 2011.
  6. Miike, K., Aoki, M., Yamashita, R., Takegawa, Y., Saya, H., Miike, T. and Yamamura, K. Proteome profiling reveals gender differences in the comparioson of human serum. Proteomics 10(14): 2678-91, 2010.
  7. Araki, K., Takeda, T., Yoshiki, A., Obata, Y., Nakagata, N., Shiroishi, T., Moriwaki, K. and Yamamura, K. Establishment of germline-competent embryonic stem cell lines from the MSM/Ms strain. Mammal. Genome 20(1): 14-20, 2009.
  8. Zhao, G., Li, Z., Araki, K., Haruna, K., Yamaguchi, K., Araki, M., Takeya, M., Ando, Y. and Yamamura, K. Inconsistency between hepatic expression and serum concentration of transthyretin in mice humanized at the transthyretin locus. Genes Cells 13(12): 1257-68, 2008.
  9. Hashimoto, D., Ohmuraya, M., Hirota, M., Yamamoto, A., Suyama, K., Baba, H., Araki, K., Mizushima, N. and Yamamura, K. Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J. Cell Biol. 181(7): 1065-72, 2008.
  10. Ohmuraya, M., Hirota, M., Araki, M., Mizushima, N., Matsui, M., Mizumoto, T., Haruna, K., Kume, S., Takeya, M., Ogawa, M., Araki, K. and Yamamura, K. Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal Type 3 deficient mice. Gastroenterology 129(2): 696-705, 2005.
  11. Takaoka, Y., Ohta, M., Miyakawa, K., Nakamura, O., Suzuki, M., Takahashi, K., Yamamura, K. and Sakaki, Y. Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Val30Met. Amr. J. Pathol. 164(1): 337-45, 2004.
  12. Pepys, M. B., Herbert, J., Hutchinson, W. L., Tennent, G. A., Lachmann, H., Gallimore, J.R., Lovat, L.B., Bartfai, T., Alanine, A., Hertel, C., Hoffmann, T., R. Jakob-Roetne, Norcross, R.D, Kemp, J. A., Yamamura, K., Suzuki, M., Taylor, G. W., Murray, S., Thompson, D., Purvis, A., Kolstoe, S., Wood, S. P. and Hawkins, P. N. Targeted pharmacological depletion of serum amyloid P component (SAP) for treatment of human amyloidosis. Nature 417(6886): 254-9, 2002.
  13. Yamauchi, Y., Abe, K., Mantani, A., Hitoshi, Y., Suzuki, M., Osuzu, F., Kuratani, S. and Yamamura, K. A novel transgenic technique that allows specific marking of the neural crest cell lineage in mice. Dev. Biol. 212(1): 191-203, 1999.
  14. Oike, Y., Hata, A., Mamiya, T., Kaname, T., Noda, Y., Suzuki, M., Yasue, H., Nabeshima, T., Araki, K. and Yamamura, K. Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: Implication of a dominant negative mechanism. Human Mol. Genet. 8(3): 387-96, 1999.
  15. Araki, K., Araki, M. and Yamamura, K. Targeted integration of DNA using mutant lox sites in embryonic stem cells. Nucleic Acid Res. 25(4): 868-872, 1997.
  16. Toyonaga, T., Hino, O., Sugai, S., Wakasugi, S., Abe, K., Shitiri, M. and Yamamura, K. Chronic active hepatitis in transgenic mice expressing interferon-g in the liver. Proc. Natl. Acad. Sci. USA. 91(2):614-8, 1994.
  17. Miyazaki, T., Matsude, Y., Toyonaga, T., Miyazaki, J., Yazaki, Y. and Yamamura, K. Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules. Proc. Natl. Acad. Sci. USA. 89(20): 9519-23, 1992.
  18. Niwa, H., Yamamura, K. and Miyazaki, J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108(2):193-9, 1991.
  19. Miyazaki, T., Uno, M., Uehira, M., Kikutani, H., Kishimoto, T., Kimoto, M. ,Nishimoto, H., Miyazaki, J.and Yamamura, K.. Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in NOD mice. Nature 345(6277): 722-4, 1990.
  20. Araki, K., Miyazaki, J., Hino, O., Tomita, N., Chisaka, O., Matsubara, K. and Yamamura, K. Expression and replication of hepatitis B virus genome in transgenic mice. Proc. Natl. Acad. Sci. USA 86(1): 207-11, 1989.
  21. Nishimoto, H., Kikutani, H., Yamamura, K. and Kishimoto, T. Prevention of autoimmune insulitis by expression of I-E molecules in NOD mice. Nature 328(6129): 432-4, 1987.
  22. Yamamura, K., Kudo, A., Ebihara, T., Kamino, K., Araki, K., Kumahara, Y. and Watanabe, T. Cell-type-specific and regulated expression of a human g1 heavy-chain immunoglobulin gene in transgenic mice. Proc. Natl. Acad. Sci. USA 83(7): 2152-6, 1986.
  23. Yamamura, K., Kikutani, H., Folsom, V., Clayton, L.K., Kimoto, M., Akira, S., Kashiwamura,S., Tonegawa, S. and Kishimoto, T. Functional expression of a microinjected Ed alpha gene in C57BL/6 transgenic mice. Nature 316(6023): 67-9,1985.

学会発表

  1. 山村研一：ヒトiPSを活用した肝臓ヒト化マウスの作製と応用, 日本人類遺伝学会第59回大会シンポジウム, 2014.11.19-11.22, 東京（タワーホール船堀）
  2. 山村研一: ヒト疾患モデルを用いた病因・病態解析と治療法の検証, 第61回日本実験動物学会総会, 2014.5.15-5.17, 北海道（札幌コンベンションセンター）【受賞講演】
  3. 山村研一: 脊椎形成の分子メカニズムの解析‐マウスからヒトへ‐, 第26回日本軟骨代謝学会, 2013.3.1-3.2, 大阪（千里ライフサイエンスセンター）【特別講演】
  4. Yamamura, K.: Production of the optimum humanized mouse model for familial amyloidotic Polyneuropathy(Key note lecture) . Ⅷth International Symposium on Familial Amyloidotic Polyneuropathy, November 20-22.2011, Kumamoto (The Kumamoto City Medical Association Hall)
  5. Yamamura, K., Araki, K., Ohmuraya, M.: Spink3 is involved in pancreatitis through the regulation of autophagy. Mouse Genetics 2011,June 22-25.2011, Washington DC USA
  6. Yamamura, K.: Humanized Mice for Functional Genomics and Human Disease Model,The4th AFLAS Congress Meeting 5th AMMRA Meeting & 11thCSLAS Annual Meeting,2010. 11.9-11,Taipei Taiwan (Taipei International Convention Center)
  7. Yamamura, K.: Pancreatic Acinar Cell Death In Spink3 Deficient Mice, 40th Anniversary Joint Meeting of the American Pancreatic Association & Japan Pancreas Society, November 4-7,2009, Hawaii
  8. Yamamura, K., Ohmuraya, M.: Role of Spink3 in autophagy regulation and induction of pancreatitis.,13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine, 2008.October 9-11,Greece
  9. Yamamura, K.: Autophagy, spink3 and pancreatitis. The 4th China-Japan Cooperative Life Science Symposium, 2007.Oct.15, China
  10. Yamamura, K.: Developmenta mutant obtained by the exchangeable gene trap mutagenesis. Joint Meeting GSF-National Research Center for Environment and Health & RIKEN Center for Developmental Biology，2006. April 13-14, Kobe.
  11. Yamamura, K.: A novel murine gene, Sickle tail(Skt), linked to the Danforth’s short　tail (Sd) locus, is required for normal development of the intervertebral disc. 15th International Society of Developmental Biologists Congress, September 3-7, 2005, Australia.
  12. Yamamura, K.: Desirable Alterations of the genome in mice for drug discovery by the exchangeable gene trap method. In Vivo and Transgenic Models, September 16-17.2004, Berlin (Kempinski Hotel Bristol)
  13. Yamamura, K.: Dissection of pathologic processes of disease by genetic approaches. The 3rd Meeting on Pathology of Genetically Engineered Mice , 2003. 10. 2-4 , Japan (Kumamoto)
  14. 山村研一：疾患モデル研究の戦術・戦略ーポストゲノム時代への視座ー「機能ゲノミクスー特にES 細胞から個体へ」. 第９０回日本病理学会総会公開シンポジウム，2001. 4.5-7，東京
  15. 山村研一：ワークショップーマウスを用いた遺伝子機能解析：21世紀への展望「マウスの遺伝子トラップミュータジェネシス」. 第121回日本薬学会，2001. 3.28-30, 札幌
  16. Yamamura, K., Araki, M., Imaizumi, T., Sekimoto, T., Araki, K.：Random Mutagenesis in Mice Using the Exchangeable Gene Trap.13th International Mouse Genome Conference, 1999.10.31-11.3, USA
  17. 山村研一：マウスにおける飽和突然変異プロジェクト. 第３９回日本先天異常学会, 1999. 7.14-16，鹿児島【特別講演】
  18. Yamamura, K.: Development of mouse models for determination of factors involved in amyloidogenesis. In Symposium V. Animal models in amyloid reseach of The 4th International Symposium on Familial Amyloidotic Polyneuropathy and Other Transthyretin Related Disorders & The 3RD International Workshop on Liver Transplantation in Familial Amyloid Polyneuropathy. June 3-5,1999, Umea, SWEDEN.
  19. 山村研一: 形づくりの研究に必要な遺伝子技術「形づくりを制御する遺伝子を探す」. 第１３回「大学と科学」公開シンポジウム-生き物の形づくり-, 1999. 1.22-23, 神戸
  20. 山村研一: ２１世紀のバイオサイエンスと健康科学における実験動物の役割「２１世紀に向かっての実験動物とその施設」. 日本学術会議・（社）日本実験動物学会主催シンポジウム，1999. 1.21，東京
  21. Yamamura, K., Oike, Y.,Imaizumi, T.,Suzuki, M., Araki, K.：Exchangeable gene trap as a tool for random mutagenesis. 12th International Mouse Genome Conference, 1998.9.29-10.3, Germany
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