Research Content

• Generation of mice in which mouse hepatocytes are replaced with the human hepatocytes, and their applications

Mice with human hepatocytes were generated by using hepatocytes induced for differentiation from human iPS cells, and an analysis system was established to evaluate their function in vivo. The aim is for disease analysis applications using the humanized-liver mice.

（Researcher in charge: Assistant Professor　Zhenghua Li）
Research results are here.
（Researcher in charge: Assistant professor　Ken Matsumoto）
Research results are here.
（Researcher in charge: Postdoctoral fellow　Mazahery Ahmad Reza Faustino）
Research results are here.
（Researcher in charge: Postdoctoral fellow　Yasumitsu Fujie）
Research results are here.
（Researcher in charge: Visiting researcher　Xiangshun Li）
Research results are here.
（Researcher in charge: Special research student　Liu Li）
Research results are here.
Details are here.

• Functional analysis of liver disease-related genes

- Familial amyloid polyneuropathy
Familial amyloid polyneuropathy is caused by a single base substitution of the TTR gene. Mutated human genes are introduced to fertilized mice eggs and a model mouse in which amyloid deposition occurs is produced. Analysis of the mice clearly showed that environmental factors such as habitat are largely responsible for development. Furthermore, for the purposes of pathological analysis and treatment development, double humanized mice with both Ttr and Rbp4 loci were developed. Currently, we are verifying therapeutic agents in collaboration with pharmaceutical companies.

（Researcher in charge: Assistant Professor　Zhenghua Li）
Research results are here.
（Researcher in charge: Visiting researcher　Xiangshun Li）
Research results are here.
（Researcher in charge: Special research student　Liu Li）
Research results are here.
 Details are here.